Home | Microdosing against depression: what does the science say?
Microdosing against depression: what does the science say?
Microdosing with psychedelics is increasingly being mentioned as a possible support in the treatment of depression. But what does the science say? Is the effect real or does the placebo effect play a role?
And what are the risks involved? Here we look at what research has been done in recent years and some people ‘s experiences.
What is microdosing?
Microdosing involves taking a small amount of a psychedelic drug, such as magic mushrooms and truffles or such as LSD, takes. Unlike high doses, which produce a strong trip, microdosing does not cause hallucinations.
The idea is that these small doses have subtle positive effects on mood, creativity and focus without interrupting your daily activities.
While there are many personal stories about the benefits of microdosing, little is known about its exact effects and long-term effects. Therefore, more and more research is being done on the effects, both by universities and independent researchers.
Microdosing and depressive symptoms: what does the science say?
A growing number of studies are examining how microdosing can help reduce depressive symptoms and other psychological symptoms. Some of the most important international studies:
- Imperial College London: Researchers found that microdosing can lead to subtle changes in the brain related to mood and creativity. Yet the question remains whether this effect is not purely due to the placebo effect.
- Maastricht University: Studies show that a small amount of psychedelics can lead to improvements in cognitive flexibility and emotional stability, two factors often impaired in depression.
- University of California, Davis: Research suggests that microdosing may have a positive effect on reducing negative thinking patterns, which plays an important role in depression.
While these results seem promising, scientists stress that more long-term studies are needed to draw definitive conclusions.
Why microdosing truffles is different from traditional antidepressants
Unlike traditional antidepressants, which are often taken daily, microdosing is usually done in cycles. For example, people who do this take a very small dose every few days.
The difference with medication is that psychedelics do not work in the same way as SSRIs, for example. Traditional antidepressants affect serotonin levels, whereas psychedelics interact with the brain in a different way. This is one of the reasons why more and more research is being done here.

Microdosing: the role of good guidance
Using psychedelics, even in small doses, requires proper supervision. This is because although psychedelics do not cause a trip in micro doses, they can still affect mood and perception.
For example, without proper guidance, people may have incorrect expectations or not know how to handle certain experiences properly. There are also risks associated with careless use of psychedelics, such as interactions with other medications or psychological sensitivities.
Therefore, it is important that people considering trying microdosing inform themselves well and, if possible, seek professional guidance.
Are there risks to microdosing?
Although microdosing is considered safe by many people, there are some potential risks to consider:
- Little known about long-term effects: Because relatively little scientific research has been done, we do not yet know the long-term effects.
- Individual sensitivity: Not everyone reacts the same to psychedelic drugs. Some people may experience increased anxiety even with a small amount.
- Legislation: In many countries, psychedelics are still under the Opium Act, which means they are not legally available everywhere. In the Netherlands, magic mushrooms and truffles are legal to buy in some forms, but like LSD remainsillegal.
Does microdosing really work?
The question of whether microdosing really works has not yet been definitively answered. The first scientific studies show interesting results, especially on mood and cognitive flexibility. Still, there remains debate about the placebo effect and the exact effects of these drugs.
For people who want to try microdosing, it is essential to be well informed and, if necessary, seek proper counseling. While microdosing is not a panacea, it can be a valuable support for some people in treating depression.
Microdosing with truffles involves taking very small amounts of psychedelic truffles without experiencing a full psychedelic effect. The effects of microdosing can include increased creativity, better focus and a positive effect on mental health.
Are you curious if microdosing is for you?

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