At the request of the government and the RIVM, this department wrote a risk analysis regarding the active substances psilocybin and psilocin in plant products such as truffles and magic mushrooms. Psilocybin is converted in the body to psilocin which acts on the serotonin receptors in the brain.
A temporary increase in serotonin and a temporary decrease in norepinephrine, dopamine and histamine concentrations is thereby achieved. It affects memory, sleep, emotions, self-confidence, mood, appetite and orgasm.
The effect of psilocybin is between 2 and 4 hours however, insights can be gained up to a month after use. In ceremonial sessions, psilocybin contributes to healing and processing of trauma.
No physical dependence
Safe for the user
No mental dependence
No risk to public order
At the request of the government and the RIVM, this department wrote a risk analysis regarding the active substances psilocybin and psilocin in plant products such as truffles and magic mushrooms. Psilocybin is converted in the body to psilocin which acts on the serotonin receptors in the brain.
A temporary increase in serotonin and a temporary decrease in norepinephrine, dopamine and histamine concentrations is thereby achieved. It affects memory, sleep, emotions, self-confidence, mood, appetite and orgasm.
The effect of psilocybin is between 2 and 4 hours however, insights can be gained up to a month after use. In ceremonial sessions, psilocybin contributes to healing and processing of trauma.
No physical dependence
No physical dependence on psilocybin forms with use. Physical dependence does not occur with psilocybin use.
Temporary physical symptoms such as dilated pupils, balance disorders, paresthesias (feeling of tingling all over the body), nausea, cold feeling and drowsiness are the most prominent features.
No mental dependence
Low toxicity
The toxicity of psilocybin has been estimated to be 1.5 times the toxicity of caffeine. Psilocybin is thus harmless to the body and poses no risk when used. Use can cause flashbacks that are limited in emotions to possible positive insights or panic or anxiety attacks. Use in a safe environment minimizes the risk of panic or anxiety attacks. The setting plays a big role in this.
Even with long-term use in the form of microdosing (where the user uses a low dose according to a schedule), no form or symptoms of chronic toxicity occur. No organ damage was detected. People who are very unstable or have mental disorders are not recommended to use psilocybin.
Half-life
In comparison, the half-life of
- cup of coffee 5 o’clock
- alcohol 1.5 hours per glass
- three glasses of wine 4.5 hours
- sugar 6.5 hours
- ecstasy / MDMA 7 hours
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